2548
Comparison of mono-exponential and three non-Gaussian diffusion models in characterizing low- and high-grade clear cell renal cell carcinoma
Bowen Shi1, Ke Xue2, Yili Yin1, Qing Xu1, Binbin Shi1, Jing Ye1, and Yongming Dai2
1Northern Jiangsu Province Hospital, Yangzhou, China, 2Shanghai United Imaging Healthcare, Shanghai, China
This study evaluated the performance of FROC, DK, bi- and mono-exponential diffusion models in differentiating low- from high-grade ccRCCs. As a result, the diffusion parameters from the FROC model outperformed the other three models in characterizing ccRCC grades.
Fig. 1: (a-h) A 59-year-old man with a high-grade ccRCC (WHO grade IV) in the left kidney. The lesion (red arrow) showed moderate signal intensity on T2-weighted image (a), (b-h) corresponding parametric maps (ADC, Ds, MD, MK, Dfroc, β and μ). (i-p) A 49-year-old woman with a low-grade ccRCC (WHO grade I) in the right kidney. The lesion (red arrow) showed high signal intensity on T2-weighted image (i), (j-p) corresponding parametric maps (ADC, Ds, MD, MK, Dfroc, β and μ).
Fig. 3: (a) ROC curves of the diagnostic performance of Dfroc, 𝛽, 𝜇, MD and MK values in distinguishing high- from low-grade ccRCCs. (b) ROC curves of the diagnostic performance of ADC and Ds values in distinguishing high- from low-grade ccRCCs.