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In Vivo Assessment Of Metabolic Abnormality In Alport Syndrome Using Hyperpolarized [1-13C]Pyruvate MR Spectroscopic Imaging
Nguyen Trong Nguyen1, Ilwoo Park2,3, Ngoc Luu Do2, Tien Anh Nguyen2, Sang Heon Suh 4, Eun Hui Bae4, and Sang Soo Shin2
1Department of Biomedical Science, Chonnam National University, Gwangju, Korea, Republic of, 2Department of Radiology, Chonnam National University Medical School and Hospital, Gwangju, Korea, Republic of, 3Department of Artificial Intelligence Convergence, Chonnam National University, Gwangju, Korea, Republic of, 4Department of Internal Medicine, Chonnam National University Hospital, Gwangju, Korea, Republic of
In this studies, we show the potential of Hyperpolarized MRI 13C technique to detect the abnormal metabolic activity of kidney in Alport Syndrome.
 
 
 
 
Figure 3. The comparison of normalized lactate and normalized pyruvate between knockout and wildtype at different time points.
Figure 2. Temporal changes in metabolites. Normalized lactate for knock-out and normalized pyruvate for wildtype are shown between 4 and 7 week-old