Leo Hebbelmann1, Lydia Wachsmuth1, Henriette Lambers1, Cornelius Faber1, Annika Lüttjohann2, and Thomas Budde2
1Translational Research Imaging Center Clinic for Radiology, University of Münster, Münster, Germany, 2Physiology I, University of Münster, Münster, Germany
1Translational Research Imaging Center Clinic for Radiology, University of Münster, Münster, Germany, 2Physiology I, University of Münster, Münster, Germany
Graph
theoretical analysis of rs-fMRI data in the GAERS rat model of absence epilepsy
under Isoflurane suggests long-term effects of seizures on brain networks in
the epileptic rat compared to non-epileptic controls.
Connectivity
differences between GAERS and NEC at 4 months (3A) and 8 months (3B) mapped on
the same-age community structure of GAERS. 56 statistically stronger
connections (thick lines) were found in GAERS, while only 15 statistically
stronger connections were found in NEC. NBS based on comparison of the 360
strongest connections at α=0.05. Only brain areas with significantly
different connections are displayed in color.
Age-dependent
connectivity differences in GAERS and NEC, mapped onto respective 4 months
community structure. In GAERS (4A) 97 stronger connections (thick lines) were
found at 4 months and 22 stronger connections were found at 8 months. In NEC
(4B) 9 stronger connections (thick lines) and 45 stronger connections were
found at 8 months. NBS based on comparison of the 360 strongest connections at α=0.05. Only brain areas with
significantly different connections are displayed in color.
