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Alteration of basal ganglia thalamo-cortical loop in hemiparkinsonian mouse model

Tomokazu Tsurugizawa¹, Yuki Nakamura^2,3,4, Yukari Nakamura^2,3,4, Assunta Pelosi^2,3,4, Boucif Djemai⁵, Clement Debacker⁶, Jean-Antoine Girault^2,3,4, and Denis Herve^2,4,7
¹Human Informatics and Interaction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan, ²Inserm UMR-S 1270, Paris, France, ³Sciences and Technology Faculty, Sorbonne Universite, Paris, France, ⁴Institut du Fer à Moulin, Paris, France, ⁵NeuroSpin/CEA-Saclay, Gif-sur-Yvette, France, ⁶Inserm, UMR1266, Paris, France, ⁷Sorbonne Universite, Paris, France

Ipsilateral thalamic nuclei are key regions for functional and structural alterations in basal ganglia-thalamo-cortical loop in hemiparkinsonian mice.

Figure 1 (A) 6-OHDA is microinjected into the medial forebrain bundle (MFB) to unilaterally lesion dopamine ascending pathways. SNc, substantia nigra pars compacta. (B) Schema of experimental protocol. fMRI data were acquired for 50 min. For functional connectivity analysis, BOLD images were analyzed in two time-windows of 10 min, 10 min before and 30 min after a L-DOPA injection.

Figure 3 ROI-ROI matrices of correlation coefficients in (A) sham-operated mice and (B) 6-OHDA-lesioned mice before injection. Color bar, correlation coefficient. Thirty-six ROIs were classified in the cortex (including somatosensory cortex), subcortex (including striatum, GPi, GPe, SNR and SNC), and thalamus (including STN, MD and CM). (C) Differences between 6-OHDA-lesioned and sham mice before L-DOPA treatment. Left lower triangle panel shows t-values and right upper triangle panel shows significant difference (p < 0.05, network based statistic). Color bar, t-values.