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Increased functional connectivity but intact memory performance in tauopathy mouse at pre-tangle stage

Ling-Yun Fan¹, Hsu-Lei Lee¹, Robert Sullivan¹, Elizabeth Coulson^1,2, Juan Carlos Polanco^1,2, and Kai-Hsiang Chuang^1,3
¹Queensland Brain Institute, University of Queensland, St Lucia, Australia, ²Clem Jones Centre for Ageing Dementia Research, University of Queensland, St Lucia, Australia, ³Centre for Advanced Imaging, University of Queensland, St Lucia, Australia

Altered functional connectivity proceeds behavioral change and overt neuropathology in young tauopathy mouse model.

Increased functional connectivity areas (red) in rTg4510 mouse. EC: Entorhinal cortex.

AT8 (1000x) immunohistochemical stain of 2.5 m/o rTg4510 (A: entorhinal cortex; B: frontal cortex) and littermate (C : Hippocampus; D: frontal cortex)