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Assessment of IDH1 Mutation Status and MGMT Promoter Methylation Status of Gliomas Using DWI, IVIM and DKI
Yan Xie1, Shihui Li1, Nanxi Shen1, Weiyin Vivian Liu2, and Wenzhen Zhu1
1Department of Radiology, Tongji Hospital, Tongji Medical College, HUST, Wuhan, China, 2MR Research, GE Healthcare, Beijing, China
Diffusion MRI parameters were able to significantly distinguish the mutation state of IDH1 in low-grade gliomas, as well as the methylation state of the MGMT promoter, but not in glioblastomas.
Figure 3 Box and whisker plots of DWI, IVIM and DKI metrics in lower-grade gliomas stratified according to IDH1 genotype (IDH1 mutant and IDH1 wild type). Boxes represent the median ± quartiles, with whiskers extending to the maximum and minimum values.
Figure 4 Box and whisker plots of DWI, IVIM and DKI metrics in lower-grade gliomas stratified according to MGMT promoter status (methylated and unmethylated). Boxes represent the median ± quartiles, with whiskers extending to the maximum and minimum values.