2584
Post-surgery network reorganization in glioma patients: a longitudinal study of functional segregation and centrality
Beatrice Federica Luciani1, Francesca Saviola1, Luca Zigiotto2,3, Stefano Tambalo1, Domenico Zacà1, Lisa Novello1, Silvio Sarubbo2,3, and Jorge Jovicich1
1CIMeC Center for Mind/Brain Sciences, University of Trento, Rovereto (Trento), Italy, 2Department of Neuroscience, Division of Neurosurgery, S.Chiara Hospital, APSS, Trento, Italy, 3Structural and Functional Connectivity Lab, S.Chiara Hospital, APSS, Trento, Italy
Left-lateralized gliomas and high-grade gliomas reduce longitudinal functional segregation and centrality after surgical resection. The Default Mode Network supports post-surgical plasticity, highlighting its relevance for pre-surgical planning.
Nodes showing a significant negative effect (β<0, p<0.05 FDR-corrected) of Time on CI (A) and BC (B) are shown in blue (non-hubs) and orange (hubs). Nodes are weighted for the statistical significance (p-value). For image display purposes, concerning CI, labels are plotted for most significant nodes (threshold 0.03).
Nodes showing a significant negative effect (β<0, p<0.05 FDR-corrected) of Time × Tumor grade on Cl in LGG patients are represented in blue (non-hubs) and orange (hubs). Nodes are weighted for the statistical significance (p-value). For image display purposes, concerning Cl, labels are plotted for most significant nodes (threshold 0.03).