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Glioblastoma Recurrence vs. Radiotherapy Injury: Combined Model of DKI and 11C-MET Using PET/MR May Increase Accuracy of Differentiation

Haodan Dang¹, Ruimin Wang¹, Jiajin Liu¹, Huaping Fu¹, Mu Lin², Jiahe Tian¹, Jinming Zhang¹, and Baixuan Xu¹
¹Department of nuclear medicine, Chinese PLA General Hospital, Beijing, China, ²2. MR Collaboration, Diagnostic Imaging, Siemens Healthcare, Shanghai, China

DKI, 11C-MET PET and histogram parameters provide complementary information about tissue. The decision-tree model combined of theses parameters has the potential to further increase diagnostic accuracy. 11C-MET PET/MR may thus contribute to the management of glioblastoma patients.

Figure 1. The PET/MR images of glioblastoma recurrence.

Figure 2. Correlation matrix of each parameter pair with significance levels for glioblastoma recurrence (right upper part) and radiotherapy injury (left lower part) groups.