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Accelerating 3D variable-flip-angle T1 mapping: a prospective study based on SUPER-CAIPIRINHA
Fan Yang1, Jian Zhang2, Guobin Li2, Jiayu Zhu2, Xin Tang1, and Chenxi Hu1
1Institute of Medical Imaging Technology, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, 2United Imaging Healthcare Co., Ltd, Shanghai, China
Prospective SUPER-CAIPIRINHA shows consistent image quality and accurate T1 quantification compared with retrospective SUPER-CAPIRINHA and the gold standard. The scan time over the entire cerebrum is reduced from more than 6 minutes to 1.5 mintues.   
Figure 2. Reconstructed 3D T1 and M0 maps of whole cerebrum for 1 healthy subject. Image quality was similar between SUPER-SENSE and SUPER-CAIPIRINHA and between retrospective and prospective reconstruction. Image fine details were truthfully preserved even for 5-fold acceleration. SUPER-SENSE and SUPER-CAIPIRINHA reduced the scan time from 6:11 minutes to 2:09 minutes and 1:29 minutes, respectively.
Figure 1. Acceleration pipeline of SUPER-CAIPIRINHA for 5-fold acceleration. Column 1 shows k-Space undersampling pattern of SUPER-CAIPIRINHA, black blocks represent points to be sampled while white blocks represent undersampled points in k-space. Severe aliasing was caused by high undersampling rate (column 2&3). Parametric maps without aliasing artifact were reconstructed by blockwise curve-fitting method of SUPER (column 4).