Reproducibility and repeatability of quantitative pCASL measurements in a 3D-printed perfusion phantom
Yiming Wang1, Limin Zhou1, Durga Udayakumar1,2, and Ananth J. Madhuranthakam1,2
1Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 2Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States
We assessed
the reproducibility and repeatability of perfusion measurements using multi-PLD
2D pCASL over 5 weeks with a 3D-printed perfusion phantom. Intra-class
correlation coefficients of measured perfusion and T1 are 0.96 and 0.94,
indicating good reproducibility and repeatability.
Figure 3. Signal intensities (open circle) and their
regression analysis results (solid line) over 20 PLDs are shown for 3 runs of
2D pCASL in one session (a), and for all 5 sessions across 5 weeks (b). Curves were
shifted horizontally slightly so that they all peak at LD+PLD = 5000 ms.
Figure 2. perfusion difference images of 20 PLDs
ranging from 0.2 s to 7.8 s from 3 runs (a, b and c) of 2D pCASL sequences in
one session, compared against images from one run (d) of another session
showing similar signal intensities.