Daniele Mascali1, Antonio Maria Chiarelli1, Ilona Lipp2,3, Anna Digiovanni4, Valentina Tomassini1,3,4, and Richard Geoffrey Wise1,3
1Institute for Advanced Biomedical Technologies,Department of Neuroscience, Imaging and Clinical Sciences, "G. D'Annunzio University" of Chieti-Pescara, Chieti, Italy, 2Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 3Cardiff University Brain Research Imaging Centre (CUBRIC) School of Psychology, Cardiff University, Cardiff, United Kingdom, 4MS Centre, Neurology Unit, SS. Annunziata University Hospital, Chieti, Italy
1Institute for Advanced Biomedical Technologies,Department of Neuroscience, Imaging and Clinical Sciences, "G. D'Annunzio University" of Chieti-Pescara, Chieti, Italy, 2Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 3Cardiff University Brain Research Imaging Centre (CUBRIC) School of Psychology, Cardiff University, Cardiff, United Kingdom, 4MS Centre, Neurology Unit, SS. Annunziata University Hospital, Chieti, Italy
We found that a reduced global grey matter hypo-perfusion
in multiple sclerosis patients is associated with greater tendency to develop
irreversible tissue damage and with worse clinical scores.
Figure 3. Scatter plots of
median GM CBF vs. clinical and cognitive
scores. R and p-values are obtained via Pearson’s correlation.
Figure 2. Scatter plots of median grey matter CBF vs. white matter lesion volumes, as
assessed by T1-weighted (left panel) or T2-weighted (central panel) images. The
right panel shows the correlation between CBF and the T1/T2 volume ratio. R and
p-values are obtained via Pearson’s correlation.