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Mapping water exchange rate change after caffeine uptake using 3D diffusion prepared arterial spin labeled perfusion MRI

Qihao Zhang¹, Jana Ivanidze², Thanh Nguyen², Pascal Spincemaille², and Yi Wang¹
¹Cornell University, New York, NY, United States, ²Weill Cornell Medical College, New York, NY, United States

A 13% decrease in water exchange rate (k_w) is observed after caffeine uptake, captured by a newly developed k_w mapping sequence using arterial spin labeling (ASL) technique.

(a) Bland Altman plot of the selected 10 brain regions of the 5 subjects. (b) The test-retest for kw of a subject.

(a) and (c) CBF and kw maps before caffeine uptake. (b) and (d) CBF and kw maps after caffeine uptake. Averaged in whole brain, a 26% decrease in CBF and 13% decrease in kw are observed.