Sara Collorone1, Marco Battiston1, Ferran Prados 1,2,3, Alberto Calvi1, Baris Kanber4, Francesco Grussu1,5, Marios Yiannakas1, Carmen Tur1,6, Rebecca Samson1, Olga Ciccarelli1,7, and Claudia A.M. Gandini Wheeler-Kingshott1,8,9
1NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London (UCL), London, United Kingdom, 2Centre for Medical Image Computing (CMIC), Department of Medical Physics and Biomedical Engineering, University College London (UCL), London, United Kingdom, 3Universitat Oberta de Catalunya, Barcelona, Spain, 4Centre for Medical Image Computing (CMIC), Department of Medical Physics and Biomedical Engineering, University College London(UCL), London, United Kingdom, 5Radiomics Group, Vall d’Hebron Institute of Oncology, Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain, 6Multiple Sclerosis Centre of Catalonia (Cemcat), Vall d’Hebron Institute of Research, Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain, 7University College London Hospitals, Biomedical Research Centre, National Institute for Health Research, London, United Kingdom, 8Department of Brain & Behavioural Sciences, University of Pavia, Pavia, Italy, 9Brain Connectivity Center Research Department, IRCCS Mondino Foundation, Pavia, Italy
1NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London (UCL), London, United Kingdom, 2Centre for Medical Image Computing (CMIC), Department of Medical Physics and Biomedical Engineering, University College London (UCL), London, United Kingdom, 3Universitat Oberta de Catalunya, Barcelona, Spain, 4Centre for Medical Image Computing (CMIC), Department of Medical Physics and Biomedical Engineering, University College London(UCL), London, United Kingdom, 5Radiomics Group, Vall d’Hebron Institute of Oncology, Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain, 6Multiple Sclerosis Centre of Catalonia (Cemcat), Vall d’Hebron Institute of Research, Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain, 7University College London Hospitals, Biomedical Research Centre, National Institute for Health Research, London, United Kingdom, 8Department of Brain & Behavioural Sciences, University of Pavia, Pavia, Italy, 9Brain Connectivity Center Research Department, IRCCS Mondino Foundation, Pavia, Italy
In progressive multiple sclerosis, iron deposition in the lesions correlates with axonal loss in the lesions and cortical grey matter. Both iron deposition and axonal loss in lesions correlate with cognitive disability.
Figure 4: Example of T1 and 3DFLAIR images, F, NDI and T2* maps in a patient. F and NDI are low in the white matter lesions while T2* values are increased.
Figure 5: Histogram of T2* distribution in the normal-appearing white matter and white matter lesions. Abbreviations: WM: white matter