Jinglei Lv1, Rui Zeng1, and Fernando Calamante1
1School of Biomedical Engineering, The University of Sydney, Sydney, Australia
1School of Biomedical Engineering, The University of Sydney, Sydney, Australia
We propose a multimodal registration method to generate an
unbiased template of fiber orientation distribution, which significantly
improves the spatial specificity of near-cortex white matter and subcortex with
low registration error.
Fig.1. Method and Experiment design. (A)-(C)
illustrates the multimodal registration and template generation. The
transformation generated with multimodal images is applied to the FOD data, which
are then averaged to generate each FOD template. (D) illustrates the population
FOD template generation based on single modality FOD-based registration.
Fig.2 FOD templates generated from 50 HCP subjects with 4 methods shown
in Fig.1. The FOD butterfly patterns (overlaid on the L0 term of the FOD
expansion, which corresponds to the total apparent fiber density). The white
boxes highlight the FODs with crossing-fibers and near-cortex white matter.
