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Correlation of negative and positive BOLD signal change in the cerebral cortex by somatosensory stimulation in mice
Tomokazu Tsurugizawa1, Boucif Djemai2, and Kazumi Kasahara1
1Human Informatics and Interaction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan, 2NeuroSpin/CEA-Saclay, Gif-sur-Yvette, France
The peak of positive BOLD responses in the contralateral S1 was correlated with the peak of negative BOLD response in the bilateral barrel cortices during the somatosensory stimulation in mice.
Figure 1 Group analysis of BOLD signal changes by the somatosensory stimulation in mice (n=7, p<0.05, FDR-corrected). Yellow rectangle shows the horizontal plane in right panel. Color bar indicates the t-values. SCbf, somatosensory cortex of barrel field; S1; primary somatosensory cortex.
Figure 2 Averaged time-course of BOLD signal changes in (A) contralateral primary somatosensory cortex (contra-S1), (B) ipsilateral primary somatosensory cortex (ipsi-S1), (C) contralateral primary somatosensory cortex barrel field (contra-Scbf), (D) ipsilateral primary somatosensory cortex barrel field (ipsi-Scbf). (E) contralateral ventral posterolateral nucleus (contra-VPL), (F) ipsilateral ventral posterolateral nucleus (ipsi-VPL). Dotted line shows 5 seconds after the end of stimulation. Data are mean ± SEM. *p < 0.05, compared to averaged baseline.