Cheng Zhou1 and Minming Zhang1
1Zhejiang University, Hangzhou, China
1Zhejiang University, Hangzhou, China
LC degeneration was an indicator
for less levodopa responsiveness. LC integrity evaluation might be an
alternative tool in predicting disease prognosis and stratifying patients into
clinical trials for improving the efficacy of levodopa.
A, B, and C: Relationships between LC integrity, the change rate
of UPDRS III score, and the change rate of somatomotor network synchronization in
PD group. D: The difference of somatomotor network synchronization among HC, PD
during OFF and ON.
Comparison of CNRLC between the HC and PD groups.
(A) Signal intensity measurements of the LC (two small red
circles) and pontine (a big red circles) from a HC; (B) and (C) The location of
LC in continuous layers (red arrow); (D) Significantly decreased CNRLC
was found in PD group when compared with HC group.
