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Magnetic resonance characteristics of iron and neuromelanin in early Parkinson’s disease: correlation with vesicular monoamine transporter 2
xueling Liu1, Pu-Yeh Wu2, and Yuxin Li1
1Department of Radiology, Huashan hospital affiliated to Fudan University, Shanghai, China, 2GE Healthcare, Beijing, China, Shang Hai, China
Our results suggested that changes of neuromelanin and susceptibility on QSM images could quantitatively reflect the pathology of EPD and could be used as imaging biomarkers for diagnosing of EPD. The SUR measured by 18F-DTBZ images could reflect the lateralization in EPD patients.
Fig 1. The volume and contrast ratio (CR) of neuromelanin, and susceptibility in the substantia nigra pars compacta in HC and EPD
Fig 2. Correlations between the contrast ratio (CR) of neuromelanin and susceptibility in the substantia nigra pars compacta in HC and EPD groups (adjusted for age and gender)