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Patient-specific hyperdirect pathway activation in DBS for Parkinson’s Disease
Alba Segura Amil1,2 and T. A. Khoa Nguyen1,2
1Department of Neurosurgery, Inselspital, University Hospital Bern, Bern, Switzerland, 2ARTORG Center for Biomedical Engineering Research, University of Bern, Bern, Switzerland
The effect threshold was at 20% of hyperdirect pathway activation, while the side effect threshold was at 2% of corticospinal tract activation. 
3D illustration of DBS leads and subcortical structures. Subthalamic nucleus in orange, volume of tissue activated in red and streamlines in dark blue.
Hyperdirect pathway activation. In blue, points corresponding to not clinical effect; in orange, points corresponding to clinical effect. Correct predictions are marked as circles and incorrect predictions as crosses.