Jochen Schmidt1, Dvir Radunsky2, Patrick Scheibe1, Noam Ben-Eliezer2,3,4, Nikolaus Weiskopf1,5, and Robert Trampel1
1Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 2Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel, 3Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel, 4Center for Advanced Imaging Innovation and Research (CAI2R), New-York University Langone Medical Center, New York, NY, United States, 5Felix Bloch Institute for Solid State Physics, Faculty of Physics and Earth Sciences, Leipzig University, Leipzig, Germany
1Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 2Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel, 3Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel, 4Center for Advanced Imaging Innovation and Research (CAI2R), New-York University Langone Medical Center, New York, NY, United States, 5Felix Bloch Institute for Solid State Physics, Faculty of Physics and Earth Sciences, Leipzig University, Leipzig, Germany
Quantitative T2 maps with sub-millimeter resolution of the human brain were acquired in vivo with a multi-echo spin-echo sequence at 7T in feasible scan time. Proper correction of B1 transmit field bias was achieved by Bloch equation simulations of the spin response to the sequence features.
Figure 3: 0.6 mm isotropic resolution image obtained by voxel-wise signal response curve matching. The inset image shows more pronounced cortical detail to appreciate the potential of the method for high-resolution mapping.
Figure 2: One-slice comparison of T2 maps produced by: (A) SSE technique, (B) MESE with mono-exponential signal modelling, (C) MESE with dictionary based EMC modelling method.
