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Inter-group Heterogeneity of Regional Homogeneity (REHO)
Yan Jiang1, Mohammed Ayoub Alaoui Mhamdi1, and Russell Butler1,2
1Bishop's University, sherbrooke, QC, Canada, 2Diagnostic Radiology, University of Sherbrooke, sherbrooke, QC, Canada
By investigating physiological contributions to REHO across 412 subjects in 9 datasets, we conclude that, due to the significant correlation with multiple artifacts of non-neuronal origin, REHO should be used with caution to infer differences in neuronal activity across groups.
Figure 5. correlation REHO vs Respiration Rate, Heart Rate, Motion Parameters and FWHM inter-group. (a) Scatter plots of REHO (before correcting the fMRI data using BlurToFWHM) vs artifects. (b) Correlation of REHO in each voxel vs artifects across 9 datasets. (c) Scatter plots of REHO (after BlurToFWHM) vs artifects. (d) Correlation of REHO in each voxel vs artifects across 9 datasets. (e) Scatter plots of REHO (after BlurToFWHM and regression) vs artifects.
Figure 2. Correlation maps of REHO vs Respiration Rate across time inter-subject heterogeneity. (a) a scatter plot showing the correlation in the cross marked voxel. (b) Average correlations between the REHO of 10 segments (3D+time data was divided across time) and the respiratory series in each voxel of each subjects. (c) Average correlation map of 9 datasets. (d) Correlation map calculated by pooling all 4120 REHO sub-bricks together.