Junxia Wang1, Sichu Wu2, Jiaming Lu1, Jilei Zhang3, Zhao Qing1,4, and Bing Zhang1
1Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University, Nanjing, China, 2The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China, 3Philips Healthcare, Shanghai, China, 4Institute for Brain Sciences, Nanjing University, Nanjing, China
1Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University, Nanjing, China, 2The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China, 3Philips Healthcare, Shanghai, China, 4Institute for Brain Sciences, Nanjing University, Nanjing, China
These findings underscored the
importance of KIBRA and gender interactions as regards to brain structural and
functional alterations, which is crucial for the neurobiological understanding
of episodic memory.
Figure1 KIBRA
rs17070145 interacts with gender on brain gray matter volume and long-range
functional connectivity density. Male KIBRA C-allele carriers showed
greater GMV in the inferior temporal gyrus, while decreased lrFCD in the left
middle temporal gyrus and left middle cingulate gyrus than male TT homozygote.
FWE correction, voxel p < 0.01, cluster p < 0.05.