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1H MRS: a tool to study age-related changes in intracellular metabolites in the deep spinal muscles?
Sarah Catherine Wayte1, Alexander Dallaway2, Andrew David Weedall1, John Hattersley3, and Adrian John Wilson3,4
1Radiology Physics, Department of Clinical Physics and Bioengineering, University Hospital, Coventry, United Kingdom, 2Centre for Sport, Exercise and Life Sciences, Coventry University, Coventry, United Kingdom, 3Coventry NIHR CRF, Human Metabolic Research Unit, University Hospital, Coventry, United Kingdom, 4Department of Physics, University of Warwick, Coventry, United Kingdom
No difference (p>0.05) in the concentration of intracellular lipids in the spinal muscles of older and younger participants; a much higher concentration of creatine in older participants (p=0.23); no correlation between metabolite concentrations. 
Figure 2. Individual values for the normalized concentrations of IMCLCH2 (left) and Cr (right) for the two groups together with the lower, median and upper quartiles.

Figure 1. An example of the raw spectrum together with the fitted IMCLCH2 and Cr components. The large peak at 1.5ppm is the methylene extracellular lipid (EMCLCH2)