3267
4D flow MRI hemodynamic quantification of pediatric patients with multi-site, multi-vender, and multi-channel machine learning segmentation
Takashi Fujiwara1, Haben Berhane2,3, Michael Baran Scott3, Zachary King2, Michal Schafer4, Brian Fonseca4, Joshua Robinson3, Cynthia Rigsby2,3, Lorna Browne4, Michael Markl3, and Alex Barker1,5
1Department of Radiology, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, CO, United States, 2Lurie Children's Hospital of Chicago, Chicago, IL, United States, 3Northwestern University, Evanston, IL, United States, 4Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, CO, United States, 5Department of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, CO, United States
We found multi-site, multi-vender 4D flow MRI datasets improved performance in cases with challenging anatomy  in segmenting large arteries, improving flow quantification of difficult cases as well as overall performance.
Fig. 3 Some examples of successful/failed (differences ≥ 10ml/cycle) hemodynamic measurements in multi-site training. Segmentations of aorta (red) and pulmonary arteries (PA, blue) from both single-site and multi-site CNN are presented with Dice scores. The letters correspond to those in Fig. 2. ToF, tetralogy of Fallot; TR, tricuspid regurgitation; HLHS, hypoplastic left heart syndrome.
Fig. 2 Bland-Altman plots for net flow in the ascending aorta (Qs, upper row) and main pulmonary trunk (Qp, lower row) quantified by site1 CNN, site2 CNN, and multi-site CNN. Institution1 data are plotted by open circles while institution2 data are shown by solid circles. Limits of agreement and mean differences are presented as green and red lines. The letter labels indicate successful and failed (differences ≥ 10ml/cycle) examples for flow quantification. The labels correspond to the segmentations shown in Fig. 3.