3372
Multi-centre, multi-vendor 7 Tesla fMRI reproducibility of hand digit representation in the human somatosensory cortex
Ian D Driver1, Rosa M Sanchez Panchuelo2, Olivier Mougin2, Michael Asghar2, James Kolasinski1, William T Clarke3, Catarina Rua4, Andrew T Morgan5, Adrian Carpenter4, Keith Muir5, David Porter5, Christopher T Rodgers4, Stuart Clare3, Richard G Wise1,6,7, Richard Bowtell2, and Susan T Francis2
1Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, United Kingdom, 2Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 3Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom, 4Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom, 5Imaging Centre of Excellence, University of Glasgow, Glasgow, United Kingdom, 6Department of Neuroscience, Imaging and Clinical Sciences, "G. D’Annunzio University" of Chieti-Pescara, Chieti, Italy, 7Institute for Advanced Biomedical Technologies, "G. D’Annunzio University" of Chieti-Pescara, Chieti, Italy
This study compares within- and across-site reproducibility of 7 T fMRI to a hand digit localization task. Good reproducibility was observed across sites, demonstrating potential benefits of multi-site 7T fMRI studies where large cohorts are required.
Figure 2: Phase maps and associated digit maps (D2-D5) defined by dividing phase into π/2 portions. Overlay shown for pFDR < 0.05. Intersection mask outline shown in white (pFDR < 0.05 hand region for all five sites). (a) Phase maps from all sessions for a single subject; (top row) all sites; (bottom row) repeat sessions at site 4. Blue border indicates data in both intra-site and inter-site analysis. (b) Phase maps from all 10 subjects for site 1. Orange border matches the session in (a).
Figure 1: Conjunction maps for five subjects showing the overlap of the hand region between sessions for both repeat sessions for a single site (intra-site) or across sites (inter-site). The five subjects were chosen to represent intra-site measures for each site.