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Combining functional and structural information for optimal planning during ultrahigh temporal resolution line-scanning
Jurjen Heij1, Luisa Raimondo1, Jeroen C.W. Siero1,2, Serge O Dumoulin1,3, Wietske van der Zwaag1, and Tomas Knapen1,3
1Spinoza Centre for Neuroimaging, Amsterdam, Netherlands, 2Radiology, University Medical Centre Utrecht, Utrecht, Netherlands, 3Experimental and Applied Psychology, VU University, Amsterdam, Netherlands
We show here the feasibility of anatomically and functionally informed planning of line-scanning fMRI experiments. Contralateral visual stimulation evoked a positive BOLD-response, while ipsilateral stimulation mostly evoked negative responses.
 
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Figure 2. Acquisition and processing workflow. Surface reconstruction and segmentations were obtained from the first MP2RAGE. The best vertex was derived from pRF-data and minimal curvature indices. A registration matrix between the MP2RAGE from session 1 and session 2 was applied to our best vertex, resulting in the optimal position in the second session.
Figure 4. Vertex position across intra-subject spaces. Two representative subjects illustrating the registration cascade to warp the vertex from surface, to session 1, to session 2. Following the procedure outlined in Figure 2, we calculated the angles of the normal with each cardinal axis to obtain a line mostly perpendicular to the patch of cortex that colocalized with the point-of-interest (neurological convention; subject left is on the left).