3465
Spaceflight Associated Neuro-Ocular Syndrome: Quantitative MRI Evaluation of Lower Body Negative Pressure as a Potential Countermeasure
Larry A. Kramer1, Khader M. Hasan1, Brandon R. Macias2, Karina J. Marshall-Goebel3, Steven S. Laurie3, Refaat E. Gabr1, Leela Chaudhary1, and Alan R. Hargens4
1Diagnostic Imaging, UTHSC-Houston, Houston, TX, United States, 2NASA, Houston, TX, United States, 3KBR, Houston, TX, United States, 4Orthopedic Surgery, UCSD, La Jolla, CA, United States
The application of lower body negative pressure in the supine position simulates physiology that is associated with upright posture thereby supporting its use as a potential countermeasure to the development of optic disc edema in astronauts exposed to long-duration spaceflight.
Bar graph with included standard deviation bars comparing volumetric blood flow of the internal carotid and vertebral arteries with and without LBNP. Note the drop in volumetric blood flow after the application of LBNP (p=.007).
Bar graph with included standard deviation bars comparing internal jugular vein cross-sectional area with and without LBNP. Note the drop in cross-sectional area after the application of LBNP (p=.03).