Mu He1, Lindsay A. Somerville1, Nicolas J. Tustison1, James Patrie1, Jaime F. Mata1, Joanne M. Cassani2, Roselove Nunoo-Asare1, Alan Ropp1, Wilson G. Miller1, Yun Michael Shim1, Talissa A. Altes2, John P. Mulger1, and Eduard E. de Lange1
1University of Virginia, Charlottesville, VA, United States, 2University of Missouri, Columbia, MO, United States
1University of Virginia, Charlottesville, VA, United States, 2University of Missouri, Columbia, MO, United States
Weighted lobar lung entropy evaluation can robustly track the dynamic airflow heterogeneity changes in asthma using 3He MRI.
Figure 4. Lobar weighted entropy analysis for the asthmatic subjects shown in Figure 3. A) the global weighted entropy decreased from 113.1 to 45.8 after BD, while the left lung and the right lower lobe contributed the most to the weighted entropy decrease. B) the global weighted entropy decreased from 53.5 to 48.7 after BD, while all the lobes except the left lower lobe contributed to the weighted entropy decrease. C) the global weighted entropy increased from 26.8 to 33.7 after BD, while the left lower lobe and right lower lobe contributed to this weighted entropy increase.
Figure 3. A) An asthma patient with FEV1%pred=39.2, FVC%pred = 88.5, and VDP = 25.4% at baseline. The weighted entropy was 113.1. B) An asthma patient with FEV1%pred=86, FVC%pred = 96, and VDP = 11.4% at baseline. The weighted entropy was 53.5. C) An aasthma patient with FEV1%pred=95.6, FVC%pred = 102.9, and VDP = 6% at baseline. The weighted entropy was 26.8.