Zhan Xu1, Christopher M Walker1, Collin J Harlan1, Keith A Michel1, Gary V Martinez1, and James A Bankson1,2
1Imaging Physics, MD Anderson Cancer Center, Houston, TX, United States, 2UT Health Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer, Houston, TX, United States
1Imaging Physics, MD Anderson Cancer Center, Houston, TX, United States, 2UT Health Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer, Houston, TX, United States
A new model-based constrained reconstruction method CoUNFOLD is introduced for hyperpolarized 13C pyruvate imaging. Accurate reconstruction was achieved using undersampled data acquired on single channel.
Data acquisition and constrained reconstruction
scheme of CoUNFOLD. P stands for a pixel
in the full FOV image, A stands for an
aliased pixel in the undersampled (R stands for the ratio) image with reduced
FOV, A’ is the estimated aliased pixel that is calculated under the same undersampling scheme as A from the CoUNFOLD
reconstructed image. The solid and dashed lines
represent, respectively, the acquired and skipped phase steps in k-space.
The time series at the same voxel location from
different undersampling rates. (a) The sampled metabolite series ('x') at SNR=30
are fluctuating along the noise free series (dash lines), while the estimated
series (solid) from pharmacokinetic model matches the noise free series with
slight offset. (b) The undersampled pyruvate series (blue 'x') at SNR=30 fluctuate drastically around the noise-free series(dashed lines) and the lactate
series(red 'x') are severely deviated, but the CoUNFOLD restored series
(solid) match the noise free series only with moderate offset.
