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Preliminary Study on Monitoring Drug Resistance of Colon Cancer with Intravoxel Incoherent Motion MRI In Vivo
Qi Xie1, Wenjuan He1, Zhilin Tan1, Yajie Wang1, Jinbin Wu1, Xiyan Shao2, Yiming Yang3, Jing Zhang4, Kangwei Wang5, Guiqin Wang6, Qifeng Pan1, and Yunzhu Wu7
1Medical Imaging Department, Nansha Hospital, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China, 2Ultrasound Imaging Department, Longgang District People’s Hospital, Shenzhen, China, 3Department of Radiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, China, 4Department of Pathology, Cancer Center, Sun Yat-sen University, Guangzhou, China, 5Department of Pathology, Nansha Hospital, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China, 6Medical Record Department, Nansha Hospital, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China, 7MR Scientific Marketing, SIEMENS Healthcare Ltd., Guangzhou, China
The ADC value of DWI and diffusion coefficient D of IVIM were moderate valuable for discriminating 5-FU-response and resistance of colon cancer in vivo.
IVIM DWI parametric maps of ADC, D, D* and f values and T2WI images for SW480 (A-E)and SW480/5-FU(F-J).
The Comparison of The ADC(a), D(b), D*(c) and f(d) values between SW480/5-FU and SW480 xenografts.