Jing Cui1, Yu Zhao1, Feng Wang1, Junzhong Xu1, Daniel Gochberg1, John Gore1, and Zhongliang Zu1
1Vanderbilt University Medical Center, Nashville, TN, United States
1Vanderbilt University Medical Center, Nashville, TN, United States
We used signal acquisition with a diffusion-weighting and injection of MION to evaluate the contribution of blood to NOE(-1.6) in rat brains. Results suggest that NOE(-1.6) is not mainly from blood,
and that MION particles alter the NOE(-1.6) but have much weaker effects on
other CEST and NOE.
Fig. 1. Averaged Z-spectra and AREX spectra for each
pool (a, b), statistics of fitted AREX
values for amide (c), NOE(-1.6) (d), and NOE(-3.5) (e) as well as S0
(f) from the whole brain with a diffusion-weighting of b = 0s/mm2 (blue)
and 400s/mm2 (red), respectively. Each AREX spectrum contains a CEST
or NOE peak from a corresponding pool and a residual water peak. The great
residual water peak is due to the use of the inverse analysis for calculating
AREX values. * P < 0.05
Fig. 3. Averaged Z-spectra and AREX spectra for each
pool (a, b), statistics of fitted AREX values for amide (c), NOE(-1.6)
(d), and NOE(-3.5) (e) as well as S0 (f) from the whole brain before
(blue) and after (red) the injection of 5 mg/kg MION, respectively. * P <
0.05