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Discrimination of IDH1 Genotype and 1p/19q Status in Glioma: A comparison study between Arterial Spin Labeling and Amide Proton Transfer imaging

DiaoHan Xiong¹, Rui Wang¹, Tao Wen¹, Yujing Li¹, Xinying Ren¹, Pengfei Wang¹, Guangyao Liu¹, Jing Zhang¹, and Kai Ai²
¹Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou, China, ²Philips Healthcare, Xi'an, China

Both APTw and 3D-pCASL have the predictive value of IDH1 Genotype and 1p/19q Status before surgery, the 3D-pCASL is btter. It may be helpful for method choosing and clinical management .

Fig 4: Two representative cases for gliomas with aligned Contrast enhancement(A,D), APTw (B,E) and 3D-pCASL.A 48-year-old female with 1p/19q codeletion type (A,B,C),shows low APTw value and low perfusion. A 58-year-old male, with 1p/19q undeletion (E,F,G),shows high APTw value and high perfusion.

Fig 2: ROC curve for APTw and 3D-pCASL in distinguishing IDH mutation type and IDH wild type. ROC curve: receiver operating characteristic curve