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Prediction of the response to induction chemotherapy using Amide Proton Transfer MRI in nasopharyngeal carcinoma
Guixiao Xu1, Hui Li1, Yueming Yuan2, Liangru Ke1, Yun He1, Yanlin Zhu1, Liyun Zhen2, Yingyi Huang1, Chuanmiao Xie1, and Yongming Dai2
1Department of Radiology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in Southern China, Guangzhou, China, 2Central Research Institute, United Imaging Healthcare, Shanghai, China
We found that the pre-treatment mean APT value was correlated to percentage change of primary tumor size negatively in NPC. This indicated the NPC pre-treatment APT value might be a useful features or biomarker of the response in IC.
Figure 2. Pre-treatment axial APTw image of a primary nasopharyngeal carcinoma in a 44-year-old woman (APTmean = 1.34%) and a 26-year-old woman (APTmean = 2.64%).
Figure 1. The correlation between mean APT value (APTmean) and percentage change (%Δ area) of primary tumor.