Rong Guo1,2, Yibo Zhao1,2, Yudu Li1,2, Pallab Bhattacharyya3, Mark Lowe3, Hannes M. Wiesner 4, Yao Li5, Xiao-Hong Zhu4, Wei Chen4, and Zhi-Pei Liang1,2
1Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 2Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 3Imaging Institute, Cleveland Clinic, Cleveland, OH, United States, 4Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 5School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China
1Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 2Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 3Imaging Institute, Cleveland Clinic, Cleveland, OH, United States, 4Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 5School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China
A rapid, high-resolution,
non-water-suppressed MRSI technique was developed at 7T. Using the SPICE
framework, the new technique can
simultaneously obtain metabolite maps at 3.0×3.0×3.0 mm3 resolution
and water signals at 1.0×1.0×3.0 mm3 resolution in an 8 min scan
with high fidelity.
Figure 4. Representative metabolite maps (NAA, Cr, Cho) and
spatially localized spectra obtained from a healthy subject using SPICE. High-quality
spatiospectral distributions of various brain metabolites were obtained.
Figure
5. Simultaneously obtained water image, QSM map, T2* map at
1.0×1.0×3.0 mm3 nominal resolution and metabolite maps of NAA, Cr
and Cho from two representative traverse images at 3.0×3.0×3.0 mm3 nominal
resolution from a healthy subject in a single 8-min scan using SPICE.