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Evaluation of the agreement of metabolite levels between PRESS and MEGA-PRESS techniques in the grading of glioma patients
Gerd Melkus1,2, Michael Taccone3,4, Ioana D Moldovan4,5, John Woulfe3,5,6, Gerard Jansen3,7, Ian Cameron1,2, Fahad AlKherayf3,4,5, and Thanh Binh Nguyen1,2
1Medical Imaging, The Ottawa Hospital, Ottawa, ON, Canada, 2Radiology, University of Ottawa, Ottawa, ON, Canada, 3University of Ottawa, Ottawa, ON, Canada, 4Division of Neurosurgery, The Ottawa Hospital, Ottawa, ON, Canada, 5The Ottawa Hospital Research Institute, Ottawa, ON, Canada, 6Division of Neurology, University of Ottawa, Ottawa, ON, Canada, 7Department of Pathology and Laboratory Medicine, The Ottawa Hospital, Ottawa, ON, Canada
T2 corrected metabolite levels of NAA, Cho and Cr obtained from the edit off spectrum of the MEGA-PRESS sequence are in good agreement with those obtained from a standard long TE PRESS sequence. No significant difference in the diagnostic accuracy was found.
Figure 4. Diagnostic accuracy of the Cho/Cr ratio in the differentiation between high grade and low grade gliomas.
Figure 1. Comparison of metabolite levels obtained from PRESS and edit-off spectrum using Bland-Altman analysis.