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Standard Frame of Reference for the Identification of Metabolic Phenotypes of Brain Tumors using Single Voxel MR Spectroscopy

Eduardo Coello¹, Victoria Sanchez¹, Marcia Louis¹, Huijun Liao¹, Sam Jiang¹, Wufan Zhao¹, Katherine M. Breedlove¹, Raymond Huang¹, and Alexander Lin¹
¹Radiology, Brigham and Women's Hospital, Boston, MA, United States

A method for the robust classification of MRS samples was developed. The model was able to correctly classify samples between tumor vs. non-tumor voxels, and IDH vs. non-IDH tumors.

Fig. 2. Distribution of the quantified metabolite ratios in the analyzed datasets. The plot shows the variability of tumor tissue samples in comparison to the normal-appearing tissue.

Fig. 4. Decision tree for the classification of tumor samples in normal-appearing tissue (normal) and tumor tissue.