Gasper Zupan1,2, Sebastian Stefanovic3, Marjana Turk Jerovsek3, Borut Stabuc3, Georg Oeltzschner4,5, Stefan Ropele6, Dusan Suput1, and Andrej Vovk1
1Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia, 2Institute of Radiology, University Medical Center Ljubljana, Ljubljana, Slovenia, 3Department of Gastroenterology and Hepatology, University Medical Center Ljubljana, Ljubljana, Slovenia, 4Russell H. Morgan Department of Radiology and Radiological Sciences, The John Hopkins University School of Medicine, Baltimore, MD, United States, 5M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 6Department of Neurology, Neuroimaging Research Unit, Medical University of Graz, Graz, Austria
1Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia, 2Institute of Radiology, University Medical Center Ljubljana, Ljubljana, Slovenia, 3Department of Gastroenterology and Hepatology, University Medical Center Ljubljana, Ljubljana, Slovenia, 4Russell H. Morgan Department of Radiology and Radiological Sciences, The John Hopkins University School of Medicine, Baltimore, MD, United States, 5M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 6Department of Neurology, Neuroimaging Research Unit, Medical University of Graz, Graz, Austria
Liver cirrhosis in a systemic disease that affects brain as well. Using advanced MR methods, we demonstrated decreased striatal GABA levels, decreased susceptibility in caudate nucleus and increased susceptibility in putamen in patients with liver cirrhosis compared to healthy controls.
Figure
4: Exemplary T1-, T2-weighted MR images and corresponding QSM (Quantitative Susceptibility
Maps) of a LC patient (upper row) and a healthy control (lower row).
Figure
2: Exemplary spectra of two LC pacients and a healthy control.