3818
Validating Open-Source MR Sequences for Reproducible Research
Gehua Tong1, Sairam Geethanath2, Enlin Qian1, and John Thomas Vaughan, Jr. 2
1Biomedical Engineering, Columbia University, New York, NY, United States, 2Columbia Magnetic Resonance Research Center, Columbia University, New York, NY, United States
A framework for testing, validating, and sharing open-source MR sequences was developed to improve their accessibility, repeatability, and safety. The framework was demonstrated for two common sequences, which were packaged and shared in an open-source repository.
Figure 2: Open-source qualitative IRSE and TSE sequences are compared to vendor gold standards. Parameters are FOV = 250 mm, N = 256, slice thickness = 5 mm, and FA = 90 deg. IRSE has TR = 2000 ms, TE = 12 ms, TI = 100 ms (125 ms for Siemens); TSE has TR = 2741 ms, TE = 50 ms, turbo factor = 4
Figure 3: T1 and T2 maps obtained from IRSE and TSE sequences (N = 128, FOV = 250 mm, slice thickness = 6 mm, FA = 90, 180 deg). The Pearson coefficient of correlation is 0.9557 for T1 spheres (0.9983 for spheres 1-13) and -0.0849 for T2 spheres (0.9994 for spheres 1-10). Shorter TIs and TEs than applied are required to accurately map the highest-index spheres.