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The value of GRASP DCE-MRI for the differentiation between benign and malignant endometrium lesions
yaling wang1, Zhongshuai Zhang2, Yuancheng Wang1, and Shenghong Ju1
1Zhongda Hospital,School of Medicine,Southeast University, NanJing, China, 2SIEMENS Healthcare, Shanghai, China
This prospective study aimed to investigate the value of GRASP(Golden-angle RAdial Sparse Parallel)on dynamic gadolinium-enhanced T1-weighted MRI(DCE-MRI)for differentiation between benign and malignant lesions of endometrium on 88 patients. 
Figure 3. A 71-year-old female with endometrial carcinoma. ROI was placed in endometrial carcinoma area and superficial myometrial area. Both A-C and E-G are the Ktrans, Kep and iAUC, respectively, D and H were DCE concentration curves of the mass and superficial myometrial layer. The calculated Ktrans, Kep and and Ve values of the mass were:0.085 min−1, 0.646 min−1, 0.131, respectively. The Ktrans, Kep and and Ve values of the superficial myometrial layer were:0.31 min−1, 0.981 min−1, 0.316, respectively.
Figure 1. The Kep distribution of benign and malignant endometrium lesions. The mean Kep values of these two group of statistical measurements are: benign: 0.627 ± 0.673min−1and malignant: 1.412 ± 1.143 min−1 (T test, p<0.01). The area under the ROC curve of Kep value is 0.82 which indicates that the Kep values have very good predictive ability for differentiation between benign and malignant endometrium lesions