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Use of intravoxel incoherent motion MRI to assess placental perfusion in normal and Fetal Growth Restricted pregnancies on their third trimester
liu xilong1, Feng jie1, Huang chantao1, Mei Yingjie2, and xu yikai1
1Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guang Zhou, China, 2Clinical science, Philips Healthcare, Guangzhou, China
IVIM MRI is a non-invasive, in vivo techniques which can assess placental perfusion quantitatively. Our study show that perfusion fraction (f) have a significantly lower in FGR. And f value moderately incresased with increasing gestational age in normal pregnancies.
a-c. Box plot of IVIM parameters for normal and FGR groups. a) standard diffusion coefficeint (D); b). pseudodiffusivity (D*); c) perfusion fraction (f). d) Scatter plot showing the perfusion fraction (f) in relation to gestational age in normal pregnancy (p = 0.01). The estimated regression line is shown in the scatter plot (R2 = 0.173).
An example of IVIM result from a FGR pregnancy (38 years, 31 gestational weeks). a) diffusion weighted image at b-value = 0 mm2/s; b) perfusion fraction (f) map, with f value of 36.4%; c) standard diffusion coefficeint (D) map, with D value of 1.46×10−3mm2/s; d) pseudodiffusivity (D*) map, with D* value of 19.9×10−3mm2/s . The ROI was draw on diffusion weighted image (b = 0 mm2/s) and then transferred to the other three maps.