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Detection of Cystathionine, 2-Hydroxyglutarate and Citrate in Oligodendrogliomas at 7T using Long-TE Semi-LASER
Uzay E Emir1,2, Natalie E Voets3, Sarah E Larkin4, Nick De Pennington4, Puneet E Plaha4, Richard E Stacey4, James E Mccullagh4, Christopher J Schofield4, Stuart E Clare3, Peter Jezzard3, Thomas Cadoux-hudson4, and Olaf E Ansorge4
1School of Health Sciences, Purdue University, West Lafayette, IN, United States, 2Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States, 3Wellcome Centre for Integrative Neuroimaging, Nuffield Dept of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 4University of Oxford, Oxford, United Kingdom
We demonstrate that long-TE semi-LASEr at 7 Tesla has the potential to allow presurgical stratification of patients with IDH-mutant glioma into those with oligodendrogliomas and astrocytomas; which is of important prognostic significance.
LCModel analysis of an IDH mutant glioma patient's spectrum with and without cystathionine in the basis set
Metabolite ratios of cystathionine over total choline in codeleted and no-codeleted gliomas