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Separation of positive and negative susceptibility contrast at 7 Tesla allows for a more detailed characterization of multiple sclerosis lesions
Julian Emmerich1,2, Frederik L. Sandig3, and Sina Straub1
1Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Faculty of Physics and Astronomy, University of Heidelberg, Heidelberg, Germany, 3Division Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
It is shown that the occurrence of bright multiple sclerosis lesions and have different origins that can either be separately observed in positive or negative susceptibility maps.
Figure 2: Positive, negative and conventional susceptibility maps, as well as a T1-weighted image for lesions from three different patients. For the enhancing lesion, additionally a contrast-enhanced T1-weighted image is shown. Lesion age is indicated on the left and lesions are ordered according to their age. Green indicates a contrast enhancing lesion, yellow arrows point to non-enhancing lesions.
Figure1: The cancellation of the susceptibility effects within the same voxel in QSM are illustrated.