Russell Murdoch1, Hanne Stotesbury2, Jamie Kawadler2, Dawn Saunders2, Fenella Kirkham2, and Karin Shmueli1
1Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 2Imaging and Biophysics, Developmental Neurosciences, UCL Great Ormond Street Institute of Child Health, London, United Kingdom
1Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 2Imaging and Biophysics, Developmental Neurosciences, UCL Great Ormond Street Institute of Child Health, London, United Kingdom
Quantitative Susceptibility Mapping showed decreased venous oxygenation (Yv) in sickle cell anaemia (SCA), with significantly lower Yv in SCA subjects with silent cerebral infarcts vs without. APAP had no significant effect on Yv in SCA but treatment compliance correlated with Yv increases.
a) Sagittal slice from the QSM in a representative sickle cell anaemia (SCA) subject with the superior sagittal sinus (SSS) region of interest overlaid in red. b) Comparison of QSM venous oxygenation (Yv) in the SSS in subjects with sickle cell anaemia (SCA) and healthy controls (HC). Significantly lower Yv was observed in the SCA group which also showed a wider range of Yv values than the HC group.
Comparison of QSM venous oxygenation (Yv) measured in the superior sagittal sinus of subjects with sickle cell anaemia (SCA) and healthy controls (HC) with (SCI+) and without (SCI-) silent cerebral infarcts (SCI). In SCA, significantly lower Yv was measured in subjects with SCI relative to those without. No significant differences in Yv were observed between the SCI+ and SCI- groups in HC subjects.
