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Characterization of prostate cancer and benign prostatic hyperplasia using IVIM-DKI with parameter-reconstruction method
Archana Vadiraj Malagi1, Virender Kumar2, Kedar Khare3, Chandan J. Das4, and Amit Mehndiratta1,5
1Centre for Biomedical Engineering, Indian Institute of Technology Delhi, New Delhi, India, 2Department of Nuclear Magnetic Resonance (NMR),, All India Institute of Medical Sciences Delhi, New Delhi, India, 3Department of Physics, Indian Institute of Technology Delhi, New Delhi, India, 4Department of Radiodiagnosis, All India Institute of Medical Sciences Delhi, New Delhi, India, 5Department of Biomedical Engineering, All India Institute of Medical Sciences Delhi, New Delhi, India
IVIM-DKI model with total variation(TV) penalty function reduced non-physiological inhomogeneity in IVIM-DKI parameter adaptively to produce better quality parameter maps. D, f, k can be used discriminate between PCa and BPH with high diagnostic performance.
Figure2 For BPH (yellow), the hyperintense region was observed on (b) ADC, (c) D, and (e) f; whereas hypointense region was observed on, (a) High b-value map, (d) D*, and (f) k of a representative patient diagnosed with PCa and BPH.
Figure4 Diagnostic performance of IVIM-DKI parameters obtained from HY and HY+TV model to differentiate from (a) Tumor vs BPH and (b) Tumor vs Healthy PZ.