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MIXTURE: A novel sequence for simultaneous morphological and quantitative imaging based on multi-interleaved 3D turbo-spin echo MRI
Masami Yoneyama1, Takayuki Sakai2, Shuo Zhang3, Daichi Murayama2, Hajime Yokota4, Yansong Zhao5, Shinji Saruya6, Masashi Suzuki6, Atsuya Watanabe7,8, Mamoru Niitsu6, and Marc Van Cauteren9
1Philips Japan, Tokyo, Japan, 2Department of Radiology, Eastern Chiba Medical Center, Chiba, Japan, 3Philips Healthcare, Hamburg, Germany, 4Department of Diagnostic Radiology and Radiation Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan, 5Philips Healthcare, Cleveland, OH, United States, 6Department of Radiology, Saitama Medical University, Saitama, Japan, 7Department of Orthopaedic Surgery, Eastern Chiba Medical Center, Chiba, Japan, 8General Medical Services, Graduate School of Medicine, Chiba University, Chiba, Japan, 9Philips Healthcare, Best, Netherlands
MIXTURE based on 3D multi-interleaved MRI offers high-resolution multi-contrast images, with or without fat suppression, and parametric maps in a single scan. Initial results in human subjects show promise for simultaneous morphological and quantitative imaging in the clinical practice.

Figure 1. Scheme of the MIXTURE T2 mapping.

T2-mapping is performed using T2-prepared 3D segmented turbo spin- echo (TSE) with variable refocusing pulse trains. Two images with different TE (TE = 0 and 50ms) were acquired with interleaved acquisition. To obtain the compatible contrasts with routine TSE images, TSE shot#1 did not apply any pre-pulses (as “PDW) and shot#2 applied both SPAIR and T2prep (as “fat-suppressed T2W”).


Figure 2. Scheme of the MIXTURE T1ρ mapping.

T1ρ mapping was performed using a twice-refocused spin-lock (SL) prepared segmented TSE sequence with spectral fat suppression. Three images with different SL preparation times (SL = 0, 25, and 50ms) were acquired with interleaved acquisition. Amplitude of the SL pulse was set to 500 Hz. TSE shot#1 did not apply any pre-pulses and later shots applied both SPAIR and SLprep.