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Evaluation of Dixon MRI Methods for Quantitative Assessment of Thigh Muscle Fatty Infiltration in Post-Traumatic Osteoarthritis
Brendan L. Eck1,2, Richard Lartey1,3, Dongxing Xie1,3, Jeehun Kim1,3, Carl S. Winalski1,2,3, Bruce M. Damon4, Xiaodong Zhong5, Kecheng Liu5, Dimitris Karampinos6, Faysal Altahawi1,2, Morgan H. Jones1,7, Kurt P. Spindler1,7, and Xiaojuan Li1,2,3
1Program of Advanced Musculoskeletal Imaging, Cleveland Clinic, Cleveland, OH, United States, 2Diagnostic Radiology, Cleveland Clinic, Cleveland, OH, United States, 3Biomedical Engineering, Cleveland Clinic, Cleveland, OH, United States, 4Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 5MR R&D Collaborations, Siemens Medical Solutions USA, Inc., Malvern, PA, United States, 6Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany, 7Orthopaedic Surgery, Orthopaedics and Rheumatology Institute, Cleveland Clinic, Cleveland, OH, United States
Monopolar gradient acquisition and magnitude-based processing improved fat fraction estimates. Vendor-independent magnitude-based processing and vendor inline processing quantified elevated hamstring muscle fat fraction in ACL-reconstructed legs.
Table 1. Comparison of average fat fraction in hamstrings muscles in the injured leg (HI) versus the contralateral leg (HC) across acquisition and quantification methods. Bold and italics indicate statistically significant difference in FF (p<0.05). Other muscle groups (quadriceps, other) were similarly compared but no significant differences were observed. In patients with hamstring autograft (right), substantial fatty infiltration was observed (red arrow).
Figure 2. Fat fraction (FF) maps from quantification methods (rows) for phantom and control at supine and prone positions (columns). Artifact is present in FattyRiot with complex processing, which appears to be position-dependent as it is similar across supine and prone orientations. Monopolar gradient with complex processing appears to reduce the amplitude of the artifact, but the pattern persists. Inline bipolar and FattyRiot monopolar magnitude are most consistent between subject positions.