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Can acquisition of pretreatment IVIM parameters in tumor predict the outcomes of osteosarcoma treated by chemotherapy? A preliminary study
Esha Baidya Kayal1, Devasenathipathy Kandasamy2, Kedar Khare3, Raju Sharma2, Sameer Bakhshi4, and Amit Mehndiratta1,5
1Centre for Biomedical Engineering, Indian Institute of Technology Delhi, New Delhi, India, 2Department of Radio diagnosis, All India Institute of Medical Sciences Delhi, New Delhi, India, 3Department of Physics, Indian Institute of Technology Delhi, New Delhi, India, 4Department of Medical Oncology, Dr. B.R. Ambedkar Institute-Rotary Cancer Hospital (IRCH), All India Institute of Medical Sciences Delhi, New Delhi, India, 5Department of Biomedical Engineering, All India Institute of Medical Sciences Delhi, New Delhi, India
Quantitative IVIM parameters may be useful for predicting outcome in patients with localized osteosarcoma. Histogram parameter 25th-percentile of D* and serum albumin level were found to have significant association with event-free-survival among patients.
Figure 1: Kaplan-Meier survival curves of the event-free-survival (EFS) demonstrate differences in patients in outcome (a) D*-25th percentile and (b) Albumin. The significant differences are 0.0081 and 0.027 respectively by log-rank test.
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