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Towards Catheter-based Intra-Arterial Spin Labeling for Perfusion Measurements
Kevin Waescher1, Simon Reiss1, Ali Caglar Özen1,2, Thomas Lottner1, and Michael Bock1
1Dept. of Radiology, Medical Physics, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, 2German Consortium for Translational Cancer Research Partner Site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany
In this study, we present in vitro results to demonstrate that arterial spin labelling using a local catheter based labelling coil provides an alternative technique for perfusion measurements during cardiovascular interventions without the use of exogenous contrast agents.
Figure 2: Frequency dependence of the labelling signal fitted with a Lorentzian (a) along with the power dependence (b). Image of the catheter (c) and map of the relative signal difference created by the labelling (d). The difference image indicates the transmit B1 profile of the labelling coil.
Figure 3: Image of the perfusion phantom setup (a) and maps of the relative signal difference between the labelled and unlabeled case for two different flow velocities (c and d). A plot of the normalized signal difference shows the exponential decay within the perfusion phantom.