4259
View Abstract / View Presentation
FMRI of Post High-Frequency Focused Ultrasound Ablation of ViM Shows Reduced Ipsilateral Thalamic and Cortical Motor Activation
Anna Crawford1, Mark Lowe1, Sean Nagel2, Daniel Lockwood1, Emmanuel Obusez1, Andre Machado2, and Stephen Jones1
1Imaging Institute, Cleveland Clinic Foundation, Cleveland, OH, United States, 2Neurological Institute, Cleveland Clinic Foundation, Cleveland, OH, United States
HIFU treatment targets the thalamus using measurements and landmarks. We explore an alternative method using 7T task-related fMRI and present preliminary data of BOLD activation in patients before and after HIFU treatment.
Figure 2: Mean statistical difference maps of pre-HIFU minus post-HIFU, using a finger tapping fMRI paradigm. Arrows show regions with decreased activation after HIFU: green, motor cortex in precentral gyrus; red, motor regions of thalamus; blue, subthalamic nucleus; magenta, globus pallidus; orange, putamen. Threshold for top panel is p=0.07; for bottom panel is p=0.02.
Figure 1: Single subject sample of finger tapping time series data from a voxel in the right motor cortex. The maximum and minimum values as indicated by red dots are 1396 and 1252 respectively.