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Comparison of Automated Thalamic Segmentation Techniques: Applications in MRgFUS Planning
Kain Kyle1, Jerome Maller2, Yael Barnett3, Stephen Tisch3, Benjamin Jonker3, Michael Barnett1, Arkiev D'Souza1, and Chenyu Wang1
1University of Sydney, Sydney, Australia, 2GE Healthcare, Sydney, Australia, 3St Vincent's Hospital Sydney, Sydney, Australia
In this investigation the clinical utility of thalamic segmentation tools FreeSurfer and THOMAS for use in MRgFUS planning.  We demonstrate that the ventral lateral nuclei segmented by FreeSurfer and THOMAS are consistent with the MRgFUS ablation target chosen by the treating clinician. 
Figure 2. Comparison of typical Freesurfer and THOMAS thalamic segmentations. TopFreesurfer thalamic segmentation VLp (red) and VLa(green). Bottom THOMAS WMnMPRAGE thalamic segmentation, VLp (yellow) and VLa (blue). Ablation segmentation is overlayed in white.
Figure 1. Volume of ablation in the FreeSurfer VLa, VLp and whole Thalamus, as a percentage of the total ablation volume.