Elizabeth Dao1, Roger Tam1, Ging-Yuek R Hsiung1, Lisanne ten Brinke1, Rachel Crockett1, Cindy K Barha1, Youngjin Yoo1, Walid al Keridy2, Stephanie H Doherty1, Alex L MacKay1, Cornelia Laule1, and Teresa Liu-Ambrose1
1University of British Columbia, Vancouver, BC, Canada, 2King Saud University, Riyadh, Saudi Arabia
1University of British Columbia, Vancouver, BC, Canada, 2King Saud University, Riyadh, Saudi Arabia
Lower normal appearing white matter myelin water fraction was associated with slower processing speed and poorer working memory in people with cerebral small vessel disease, after accounting for age, education, and white matter hyperintensity volume.
Figure 1 A) PD-weighted scan for WMH segmentation; B) T2-weighted scan for white matter hyperintensity segmentation; C) white matter hyperintensity mask; D) myelin water fraction map; E) normal appearing white matter myelin water fraction mask; F) normal appearing white matter myelin water fraction map
Table 2 Multiple Linear Regression Results
Independent Variables in Step 1 = age and education; Independent Variables in Step 2 = age, education, and white matter hyperintensity volume; Independent Variables in Step 3 = age, education, white matter hyperintensity volume, and normal appearing white matter (NAWM) myelin water fraction (MWF)
*Significant at p ≤ 0.05
